Neurovascular Coupling During Cortical Spreading Depolarization and –Depression

Spreading depression and neurovascular coupling.

Focussed Research Group Cerebral Blood Flow, Neurovascular Coupling, and Cortical Spreading Depression Organizers:

Due to the complexity of the multiple topics discussed at this workshop, the group of participants possess diverse and complementary expertise. Here is a brief description of the participants. K.C. Brennan (Utah, Neuroscience) Brennan is a neurologist with interests in headache. His research explores the effects of CSD on blood vessels and vice versa. J.C. Chang (Ohio State, Math. Biosciences I...

Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.

Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are characterized by rapid and nearly complete depolarization of a sizable population of brain cells with massive redistribution of ions between intracellular and extracellular compartments, that evolves as a regenerative, "all-or-none" type process, and propagates slowly as a wave in brain tissue. This article revie...

Interplay between Cortical Spreading Depolarization and Seizures.

Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies obser...

Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.

Neuronal activity in the brain is thought to be coupled to cerebral arterioles (functional hyperemia) through Ca2+ signals in astrocytes. Although functional hyperemia occurs rapidly, within seconds, such rapid signaling has not been demonstrated in situ, and Ca2+ measurements in parenchymal arterioles are still lacking. Using a laser scanning confocal microscope and fluorescence Ca2+ indicator...